Tissue expression of HTN3 - Summary - The Human Protein Atlas

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HTN3

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	HTN3
Gene description	Histatin 3
Protein class	Predicted secreted proteins Transporters
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (salivary gland)
GTEx:	Tissue enriched (pituitary gland)
FANTOM5:	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in salivary gland

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB073541
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (salivary gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (salivary gland)

GENE INFORMATION
Gene name	HTN3 (HGNC Symbol)
Synonyms	HIS2
Description	Histatin 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	70028413 - 70036538
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205649 (version 83.38)
Entrez gene	3347
UniProt	P15516 (UniProt - Evidence at protein level)
neXtProt	NX_P15516
Antibodypedia	HTN3 antibodies

PROTEIN BROWSER

HTN3-001	HTN3-006	HTN3-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HTN3-001 ENSP00000437158 ENST00000526767	P15516 [Direct mapping] Histatin-3 Histatin-3 His3-(20-44)-peptide His3-(20-43)-peptide His3-(20-32)-peptide His3-(20-31)-peptide His3-(20-30)-peptide His3-(24-32)-peptide His3-(24-31)-peptide His3-(24-30)-peptide His3-(25-32)-peptide His3-(25-30)-peptide His3-(26-32)-peptide His3-(26-31)-peptide His3-(26-30)-peptide His3-(31-51)-peptide His3-(31-44)-peptide His3-(31-43)-peptide His3-(32-44)-peptide His3-(32-43)-peptide His3-(33-44)-peptide His3-(33-43)-peptide His3-(34-44)-peptide His3-(34-43)-peptide His3-(45-51)-peptide His3-(47-51)-peptide His3-(48-51)-peptide Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0031214 [biomineral tissue development] GO:0031640 [killing of cells of other organism] GO:0042742 [defense response to bacterium] GO:0046872 [metal ion binding] GO:0050832 [defense response to fungus] Show all	51 aa 6.1 kDa	Yes	0
HTN3-006 ENSP00000432561 ENST00000530128	P15516 [Direct mapping] Histatin-3 Histatin-3 His3-(20-44)-peptide His3-(20-43)-peptide His3-(20-32)-peptide His3-(20-31)-peptide His3-(20-30)-peptide His3-(24-32)-peptide His3-(24-31)-peptide His3-(24-30)-peptide His3-(25-32)-peptide His3-(25-30)-peptide His3-(26-32)-peptide His3-(26-31)-peptide His3-(26-30)-peptide His3-(31-51)-peptide His3-(31-44)-peptide His3-(31-43)-peptide His3-(32-44)-peptide His3-(32-43)-peptide His3-(33-44)-peptide His3-(33-43)-peptide His3-(34-44)-peptide His3-(34-43)-peptide His3-(45-51)-peptide His3-(47-51)-peptide His3-(48-51)-peptide Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0031214 [biomineral tissue development] GO:0031640 [killing of cells of other organism] GO:0042742 [defense response to bacterium] GO:0046872 [metal ion binding] GO:0050832 [defense response to fungus] Show all	51 aa 6.1 kDa	Yes	0
HTN3-010 ENSP00000370445 ENST00000381057	X6RAH8 [Direct mapping] Histatin-3 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0042742 [defense response to bacterium] Show all	41 aa 4.8 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.