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OLIG2

GENERAL INFORMATION

Gene name

 OLIG2

Gene description

 Oligodendrocyte lineage transcription factor 2

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (HMC-1, NB-4, THP-1)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective nuclear expression in subsets of glial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA003254 , CAB019381
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA003254
CAB019381

GENE INFORMATION

Gene name

 OLIG2 (HGNC Symbol)

Synonyms

 BHLHB1, bHLHe19, OLIGO2, PRKCBP2, RACK17

Description

 Oligodendrocyte lineage transcription factor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.11

Chromosome location (bp)

 33025845 - 33029196

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000205927 (version 83.38)

Entrez gene

 10215

UniProt

 Q13516 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q13516

Antibodypedia

 OLIG2 antibodies

PROTEIN BROWSER
OLIG2-001
OLIG2-002
OLIG2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OLIG2-001
ENSP00000371794
ENST00000382357
Q13516 [Direct mapping]
Oligodendrocyte transcription factor 2
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Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
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 323 aa
32.4 kDa 		No 0
OLIG2-002
ENSP00000331040
ENST00000333337
Q13516 [Direct mapping]
Oligodendrocyte transcription factor 2
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Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007399 [nervous system development]
GO:0021522 [spinal cord motor neuron differentiation]
GO:0021529 [spinal cord oligodendrocyte cell differentiation]
GO:0021530 [spinal cord oligodendrocyte cell fate specification]
GO:0021794 [thalamus development]
GO:0042552 [myelination]
GO:0042803 [protein homodimerization activity]
GO:0045665 [negative regulation of neuron differentiation]
GO:0046983 [protein dimerization activity]
GO:0048663 [neuron fate commitment]
GO:0048709 [oligodendrocyte differentiation]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0071837 [HMG box domain binding]
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 323 aa
32.4 kDa 		No 0
OLIG2-003
ENSP00000391183
ENST00000430860
C9J444 [Direct mapping]
Oligodendrocyte transcription factor 2
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
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 62 aa
6.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.