Expression of SERPINB5 in cancer - Summary

GENERAL INFORMATION
Gene name	SERPINB5
Gene description	Serpin peptidase inhibitor, clade B (ovalbumin), member 5
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Group enriched (HaCaT, hTCEpi)
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with varying intensity in most tissues, most abundant in squamous epithelia and the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 4 antibodies. HPA019025 , HPA019132 , HPA020136 , CAB009570
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Pancreatic cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA019025	HPA019132	HPA020136	CAB009570

GENE INFORMATION
Gene name	SERPINB5 (HGNC Symbol)
Synonyms	maspin, PI5
Description	Serpin peptidase inhibitor, clade B (ovalbumin), member 5 (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	q21.33
Chromosome location (bp)	63476761 - 63505085
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000206075 (version 83.38)
Entrez gene	5268
UniProt	P36952 (UniProt - Evidence at protein level)
neXtProt	NX_P36952
Antibodypedia	SERPINB5 antibodies

PROTEIN BROWSER

SERPINB5-001	SERPINB5-002	SERPINB5-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINB5-001 ENSP00000372221 ENST00000382771	P36952 [Direct mapping] Serpin B5 A0A024R2B6 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade B (Ovalbumin), member 5, isoform CRA_b Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002009 [morphogenesis of an epithelium] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006928 [movement of cell or subcellular component] GO:0010951 [negative regulation of endopeptidase activity] GO:0030198 [extracellular matrix organization] GO:0050678 [regulation of epithelial cell proliferation] GO:0060512 [prostate gland morphogenesis] GO:0070062 [extracellular exosome] Show all	375 aa 42.1 kDa	No	0
SERPINB5-002 ENSP00000467158 ENST00000489441	P36952 [Direct mapping] Serpin B5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006928 [movement of cell or subcellular component] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	231 aa 25.8 kDa	No	0
SERPINB5-003 ENSP00000408821 ENST00000424602	C9JLM5 [Direct mapping] Serpin B5 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0010951 [negative regulation of endopeptidase activity] Show all	129 aa 14.4 kDa	No	0