Tissue expression of ACKR1 - Summary - The Human Protein Atlas

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ACKR1

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ACKR1
Gene description	Atypical chemokine receptor 1 (Duffy blood group)
Protein class	Blood group antigen proteins CD markers G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Selective expression in endothelial cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA016421 , HPA017672
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ACKR1 (HGNC Symbol)
Synonyms	CCBP1, CD234, DARC, Dfy, FY, GPD
Description	Atypical chemokine receptor 1 (Duffy blood group) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q23.2
Chromosome location (bp)	159203307 - 159206500
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213088 (version 83.38)
Entrez gene	2532
UniProt	Q16570 (UniProt - Evidence at protein level)
neXtProt	NX_Q16570
Antibodypedia	ACKR1 antibodies

PROTEIN BROWSER

ACKR1-001	ACKR1-002	ACKR1-003	ACKR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACKR1-001 ENSP00000357104 ENST00000368122	Q16570 [Direct mapping] Atypical chemokine receptor 1 Q5Y7A2 [Target identity:100%; Query identity:100%] Duffy antigen/atypical chemokine receptor; Duffy antigen/chemokine receptor isoform b; Duffy blood group; cDNA FLJ75122, highly similar to Homo sapiens Duffy blood group, chemokine receptor, mRNA Show all	CD markers Blood group antigen proteins G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0006952 [defense response] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0019957 [C-C chemokine binding] GO:0032642 [regulation of chemokine production] GO:0055037 [recycling endosome] GO:0070098 [chemokine-mediated signaling pathway] Show all	336 aa 35.6 kDa	No	7
ACKR1-002 ENSP00000357103 ENST00000368121	Q16570 [Direct mapping] Atypical chemokine receptor 1 Q5Y7A1 [Target identity:100%; Query identity:100%] Duffy antigen/chemokine receptor isoform a; Duffy blood group Show all	CD markers Blood group antigen proteins G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0006952 [defense response] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0019957 [C-C chemokine binding] GO:0032642 [regulation of chemokine production] GO:0055037 [recycling endosome] GO:0070098 [chemokine-mediated signaling pathway] Show all	338 aa 35.7 kDa	No	7
ACKR1-003 ENSP00000398406 ENST00000435307	Q5JY94 [Direct mapping] Atypical chemokine receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0006954 [inflammatory response] GO:0016021 [integral component of membrane] GO:0019956 [chemokine binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	155 aa 16.4 kDa	No	3
ACKR1-201 ENSP00000441985 ENST00000537147	Q16570 [Direct mapping] Atypical chemokine receptor 1 Q5Y7A2 [Target identity:100%; Query identity:100%] Duffy antigen/atypical chemokine receptor; Duffy antigen/chemokine receptor isoform b; Duffy blood group; cDNA FLJ75122, highly similar to Homo sapiens Duffy blood group, chemokine receptor, mRNA Show all	CD markers Blood group antigen proteins G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0006952 [defense response] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0019957 [C-C chemokine binding] GO:0032642 [regulation of chemokine production] GO:0055037 [recycling endosome] GO:0070098 [chemokine-mediated signaling pathway] Show all	336 aa 35.6 kDa	No	7

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