Cell atlas - ASIC3 - The Human Protein Atlas

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ASIC3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ASIC3
Gene description	Acid sensing (proton gated) ion channel 3
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Cell line enhanced (U-266/70)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049155
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049155	A549	Nucleoplasm
	HPA049155	A549	Cytosol
	HPA049155	MCF7	No staining
	HPA049155	U-2 OS	No staining

GENE INFORMATION
Gene name	ASIC3 (HGNC Symbol)
Synonyms	ACCN3, DRASIC, TNaC1
Description	Acid sensing (proton gated) ion channel 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
Chromosome	7
Cytoband	q36.1
Chromosome location (bp)	151048292 - 151052756
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213199 (version 83.38)
Entrez gene	9311
UniProt	Q9UHC3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHC3
Antibodypedia	ASIC3 antibodies

PROTEIN BROWSER

ASIC3-001	ASIC3-003	ASIC3-005	ASIC3-007	ASIC3-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASIC3-001 ENSP00000350600 ENST00000357922	Q9UHC3 [Direct mapping] Acid-sensing ion channel 3 A0A090N8Z6 [Target identity:100%; Query identity:100%] Amiloride-sensitive cation channel 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005261 [cation channel activity] GO:0005272 [sodium channel activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0007165 [signal transduction] GO:0007600 [sensory perception] GO:0015280 [ligand-gated sodium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0050915 [sensory perception of sour taste] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	543 aa 60.3 kDa	No	2
ASIC3-003 ENSP00000344838 ENST00000349064	Q9UHC3 [Direct mapping] Acid-sensing ion channel 3 A0A090N7X8 [Target identity:100%; Query identity:100%] Amiloride-sensitive cation channel 3; Amiloride-sensitive cation channel 3, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005261 [cation channel activity] GO:0005272 [sodium channel activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0007165 [signal transduction] GO:0007600 [sensory perception] GO:0015280 [ligand-gated sodium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0050915 [sensory perception of sour taste] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	531 aa 58.9 kDa	No	2
ASIC3-005 ENSP00000297512 ENST00000297512	Q9UHC3 [Direct mapping] Acid-sensing ion channel 3 A0A090N8Q1 [Target identity:100%; Query identity:100%] Amiloride-sensitive cation channel 3; Amiloride-sensitive cation channel 3, isoform CRA_d Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005261 [cation channel activity] GO:0005272 [sodium channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0007165 [signal transduction] GO:0007600 [sensory perception] GO:0009408 [response to heat] GO:0009612 [response to mechanical stimulus] GO:0010447 [response to acidic pH] GO:0015280 [ligand-gated sodium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030165 [PDZ domain binding] GO:0034220 [ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042930 [enterobactin transport] GO:0042931 [enterobactin transporter activity] GO:0050907 [detection of chemical stimulus involved in sensory perception] GO:0050915 [sensory perception of sour taste] GO:0050961 [detection of temperature stimulus involved in sensory perception] GO:0050965 [detection of temperature stimulus involved in sensory perception of pain] GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain] GO:0050968 [detection of chemical stimulus involved in sensory perception of pain] GO:0050974 [detection of mechanical stimulus involved in sensory perception] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	549 aa 60.5 kDa	No	2
ASIC3-007 ENSP00000418361 ENST00000490540	H7C4W0 [Direct mapping] Acid-sensing ion channel 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005272 [sodium channel activity] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] Show all	149 aa 16.6 kDa	No	1
ASIC3-009 ENSP00000420371 ENST00000485929	H7C5N6 [Direct mapping] Acid-sensing ion channel 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005272 [sodium channel activity] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] Show all	144 aa 15.9 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.