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ASIC3

GENERAL INFORMATION

Gene name

 ASIC3

Gene description

 Acid sensing (proton gated) ion channel 3

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Cell line enhanced (U-266/70)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expressed in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Caution, Splice and/or transcript discrepancy exists. Pending retesting.

Reliability score

 Approved based on 1 antibody.
HPA049155
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049155

GENE INFORMATION

Gene name

 ASIC3 (HGNC Symbol)

Synonyms

 ACCN3, DRASIC, TNaC1

Description

 Acid sensing (proton gated) ion channel 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Chromosome

 7

Cytoband

 q36.1

Chromosome location (bp)

 151048292 - 151052756

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213199 (version 83.38)

Entrez gene

 9311

UniProt

 Q9UHC3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHC3

Antibodypedia

 ASIC3 antibodies

PROTEIN BROWSER
ASIC3-001
ASIC3-003
ASIC3-005
ASIC3-007
ASIC3-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASIC3-001
ENSP00000350600
ENST00000357922
Q9UHC3 [Direct mapping]
Acid-sensing ion channel 3
A0A090N8Z6 [Target identity:100%; Query identity:100%]
Amiloride-sensitive cation channel 3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005261 [cation channel activity]
GO:0005272 [sodium channel activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006814 [sodium ion transport]
GO:0007165 [signal transduction]
GO:0007600 [sensory perception]
GO:0015280 [ligand-gated sodium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0050915 [sensory perception of sour taste]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
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 543 aa
60.3 kDa 		No 2
ASIC3-003
ENSP00000344838
ENST00000349064
Q9UHC3 [Direct mapping]
Acid-sensing ion channel 3
A0A090N7X8 [Target identity:100%; Query identity:100%]
Amiloride-sensitive cation channel 3; Amiloride-sensitive cation channel 3, isoform CRA_b
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005261 [cation channel activity]
GO:0005272 [sodium channel activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006814 [sodium ion transport]
GO:0007165 [signal transduction]
GO:0007600 [sensory perception]
GO:0015280 [ligand-gated sodium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0050915 [sensory perception of sour taste]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
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 531 aa
58.9 kDa 		No 2
ASIC3-005
ENSP00000297512
ENST00000297512
Q9UHC3 [Direct mapping]
Acid-sensing ion channel 3
A0A090N8Q1 [Target identity:100%; Query identity:100%]
Amiloride-sensitive cation channel 3; Amiloride-sensitive cation channel 3, isoform CRA_d
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005261 [cation channel activity]
GO:0005272 [sodium channel activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0006814 [sodium ion transport]
GO:0007165 [signal transduction]
GO:0007600 [sensory perception]
GO:0009408 [response to heat]
GO:0009612 [response to mechanical stimulus]
GO:0010447 [response to acidic pH]
GO:0015280 [ligand-gated sodium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030165 [PDZ domain binding]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042930 [enterobactin transport]
GO:0042931 [enterobactin transporter activity]
GO:0050907 [detection of chemical stimulus involved in sensory perception]
GO:0050915 [sensory perception of sour taste]
GO:0050961 [detection of temperature stimulus involved in sensory perception]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain]
GO:0050968 [detection of chemical stimulus involved in sensory perception of pain]
GO:0050974 [detection of mechanical stimulus involved in sensory perception]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
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 549 aa
60.5 kDa 		No 2
ASIC3-007
ENSP00000418361
ENST00000490540
H7C4W0 [Direct mapping]
Acid-sensing ion channel 3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005272 [sodium channel activity]
GO:0006814 [sodium ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
Show all
 149 aa
16.6 kDa 		No 1
ASIC3-009
ENSP00000420371
ENST00000485929
H7C5N6 [Direct mapping]
Acid-sensing ion channel 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005272 [sodium channel activity]
GO:0006814 [sodium ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
Show all
 144 aa
15.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.