Expression of CSH2 in cancer - Summary - The Human Protein Atlas

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CSH2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CSH2
Gene description	Chorionic somatomammotropin hormone 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Cell line enriched (BEWO)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in trophoblastic cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 1 antibody. HPA043715
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043715

GENE INFORMATION
Gene name	CSH2 (HGNC Symbol)
Synonyms	CS-2, CSB, hCS-B
Description	Chorionic somatomammotropin hormone 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	63872012 - 63881863
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213218 (version 83.38)
Entrez gene	1443
UniProt	P0DML3 (UniProt - Evidence at protein level)
neXtProt	NX_P0DML3
Antibodypedia	CSH2 antibodies

PROTEIN BROWSER

CSH2-001	CSH2-002	CSH2-004	CSH2-201	CSH2-202	CSH2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSH2-001 ENSP00000376623 ENST00000392886	P0DML3 [Direct mapping] Chorionic somatomammotropin hormone 2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] GO:0031988 [membrane-bounded vesicle] GO:0046872 [metal ion binding] Show all	217 aa 25 kDa	Yes	0
CSH2-002 ENSP00000453452 ENST00000560142	H0YM39 [Direct mapping] Chorionic somatomammotropin hormone 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	160 aa 18.4 kDa	Yes	0
CSH2-004 ENSP00000338816 ENST00000336844	P0DML3 [Direct mapping] Chorionic somatomammotropin hormone 2 A6NIT4 [Target identity:100%; Query identity:100%] Chorionic somatomammotropin hormone 2 isoform 2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] GO:0031988 [membrane-bounded vesicle] GO:0046872 [metal ion binding] Show all	167 aa 18.8 kDa	Yes	0
CSH2-201 ENSP00000308396 ENST00000345366	P0DML3 [Direct mapping] Chorionic somatomammotropin hormone 2 B1A4H9 [Target identity:100%; Query identity:100%] Chorionic somatomammotropin hormone 2 isoform 3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] GO:0031988 [membrane-bounded vesicle] GO:0046872 [metal ion binding] Show all	122 aa 13.9 kDa	Yes	0
CSH2-202 ENSP00000478842 ENST00000613718	A0A087WUG6 [Direct mapping] Chorionic somatomammotropin hormone 1; Chorionic somatomammotropin hormone 2 Show all	Predicted intracellular proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	128 aa 15 kDa	No	0
CSH2-203 ENSP00000480793 ENST00000620751	A0A087WX75 [Direct mapping] Chorionic somatomammotropin hormone 2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	222 aa 25.5 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.