Cell atlas - DDX47 - The Human Protein Atlas

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DDX47

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	DDX47
Gene description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (validated)

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA014855
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014855	A-431	Nucleoli
	HPA014855	U-2 OS	Nucleoli
	HPA014855	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	DDX47 (HGNC Symbol)
Synonyms	DKFZp564O176, FLJ30012, HQ0256, RRP3
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.1
Chromosome location (bp)	12813316 - 12829981
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213782 (version 83.38)
Entrez gene	51202
UniProt	Q9H0S4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H0S4
Antibodypedia	DDX47 antibodies

PROTEIN BROWSER

DDX47-001	DDX47-002	DDX47-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX47-001 ENSP00000350698 ENST00000358007	Q9H0S4 [Direct mapping] Probable ATP-dependent RNA helicase DDX47 A0A024RAS3 [Target identity:100%; Query identity:100%] HCG27698, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010501 [RNA secondary structure unwinding] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] Show all	455 aa 50.6 kDa	No	0
DDX47-002 ENSP00000319578 ENST00000352940	Q9H0S4 [Direct mapping] Probable ATP-dependent RNA helicase DDX47 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010501 [RNA secondary structure unwinding] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] Show all	406 aa 45.2 kDa	No	0
DDX47-009 ENSP00000444000 ENST00000544400	F5H1N9 [Direct mapping] Probable ATP-dependent RNA helicase DDX47 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	196 aa 22 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.