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DDX47

GENERAL INFORMATION

Gene name

 DDX47

Gene description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nucleolar expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA014855
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA014855

GENE INFORMATION

Gene name

 DDX47 (HGNC Symbol)

Synonyms

 DKFZp564O176, FLJ30012, HQ0256, RRP3

Description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p13.1

Chromosome location (bp)

 12813316 - 12829981

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213782 (version 83.38)

Entrez gene

 51202

UniProt

 Q9H0S4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H0S4

Antibodypedia

 DDX47 antibodies

PROTEIN BROWSER
DDX47-001
DDX47-002
DDX47-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX47-001
ENSP00000350698
ENST00000358007
Q9H0S4 [Direct mapping]
Probable ATP-dependent RNA helicase DDX47
A0A024RAS3 [Target identity:100%; Query identity:100%]
HCG27698, isoform CRA_a
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0006364 [rRNA processing]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0044822 [poly(A) RNA binding]
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 455 aa
50.6 kDa 		No 0
DDX47-002
ENSP00000319578
ENST00000352940
Q9H0S4 [Direct mapping]
Probable ATP-dependent RNA helicase DDX47
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0006364 [rRNA processing]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0044822 [poly(A) RNA binding]
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 406 aa
45.2 kDa 		No 0
DDX47-009
ENSP00000444000
ENST00000544400
F5H1N9 [Direct mapping]
Probable ATP-dependent RNA helicase DDX47
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0010501 [RNA secondary structure unwinding]
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 196 aa
22 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.