Cell atlas - MRPL23 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MRPL23
Gene description	Mitochondrial ribosomal protein L23
Protein class	Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleoli (fibrillar center). Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (HEK 293)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Additional location	In addition localized to the Nucleoli fibrillar center (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA050406
	SHOW MORE

ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEK 293) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleoli (fibrillar center). Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Mitochondria (supported)

Additional location

Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA050406	HEK 293	Nucleoli fibrillar center	Intensity
HPA050406	HEK 293	Mitochondria
HPA050406	PC-3	Nucleoli fibrillar center	Intensity
HPA050406	PC-3	Mitochondria
HPA050406	U-2 OS	Nucleoli fibrillar center	Intensity
HPA050406	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	MRPL23 (HGNC Symbol)
Synonyms	L23MRP, RPL23L
Description	Mitochondrial ribosomal protein L23 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	1947278 - 1984522
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000214026 (version 83.38)
Entrez gene	6150
UniProt	Q16540 (UniProt - Evidence at protein level)
neXtProt	NX_Q16540
Antibodypedia	MRPL23 antibodies

PROTEIN BROWSER

MRPL23-001	MRPL23-002	MRPL23-007	MRPL23-009	MRPL23-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL23-001 ENSP00000380466 ENST00000397298	Q16540 [Direct mapping] 39S ribosomal protein L23, mitochondrial A0A024RCB2 [Target identity:100%; Query identity:100%] Mitochondrial ribosomal protein L23, isoform CRA_a Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	153 aa 17.8 kDa	No	0
MRPL23-002 ENSP00000370925 ENST00000381514	A6NJD9 [Direct mapping] 39S ribosomal protein L23, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	163 aa 18.5 kDa	No	0
MRPL23-007 ENSP00000370930 ENST00000381519	Q16540 [Direct mapping] 39S ribosomal protein L23, mitochondrial A0A024RCB2 [Target identity:100%; Query identity:100%] Mitochondrial ribosomal protein L23, isoform CRA_a Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	153 aa 17.8 kDa	No	0
MRPL23-009 ENSP00000380465 ENST00000397297	A8MYK1 [Direct mapping] 39S ribosomal protein L23, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	191 aa 21.8 kDa	No	0
MRPL23-011 ENSP00000380462 ENST00000397294	A8MVT4 [Direct mapping] 39S ribosomal protein L23, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	166 aa 18.8 kDa	No	0