Expression of ARHGEF33 in cancer - Summary - The Human Protein Atlas

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ARHGEF33

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARHGEF33
Gene description	Rho guanine nucleotide exchange factor (GEF) 33
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BEWO, SiHa)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in cerebellum.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Paired antibodies with high similarity support the expression profile.
Reliability score	Supported based on 2 antibodies. HPA034661 , HPA041051
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034661	HPA041051

GENE INFORMATION
Gene name	ARHGEF33
Synonyms
Description	Rho guanine nucleotide exchange factor (GEF) 33 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p22.1
Chromosome location (bp)	38889880 - 38975449
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000214694 (version 83.38)
Entrez gene	100271715
UniProt	A8MVX0 (UniProt - Evidence at transcript level)
neXtProt	NX_A8MVX0
Antibodypedia	ARHGEF33 antibodies

PROTEIN BROWSER

ARHGEF33-001	ARHGEF33-004	ARHGEF33-006	ARHGEF33-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGEF33-001 ENSP00000387020 ENST00000409978	A8MVX0 [Direct mapping] Rho guanine nucleotide exchange factor 33 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	870 aa 97.5 kDa	No	0
ARHGEF33-004 ENSP00000413620 ENST00000433605	H7C3S6 [Direct mapping] Rho guanine nucleotide exchange factor 33 Show all	Predicted intracellular proteins Show all		108 aa 12.2 kDa	No	0
ARHGEF33-006 ENSP00000399688 ENST00000411874	H7C1C9 [Direct mapping] Rho guanine nucleotide exchange factor 33 Show all	Predicted intracellular proteins Show all		109 aa 12.2 kDa	No	0
ARHGEF33-201 ENSP00000381780 ENST00000398800	A8MVX0 [Direct mapping] Rho guanine nucleotide exchange factor 33 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	870 aa 97.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.