Expression of MYL5 in cancer - Summary - The Human Protein Atlas

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MYL5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MYL5
Gene description	Myosin, light chain 5, regulatory
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 2 antibodies. HPA037381 , HPA039262
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037381	HPA039262

GENE INFORMATION
Gene name	MYL5
Synonyms
Description	Myosin, light chain 5, regulatory (HGNC Symbol)
Entrez gene summary	This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in fetal muscle and in adult retina, cerebellum, and basal ganglia. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	673580 - 682033
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000215375 (version 83.38)
Entrez gene	4636
UniProt	Q02045 (UniProt - Evidence at transcript level)
neXtProt	NX_Q02045
Antibodypedia	MYL5 antibodies

PROTEIN BROWSER

MYL5-001	MYL5-002	MYL5-004	MYL5-008	MYL5-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYL5-001 ENSP00000383023 ENST00000400159	Q02045 [Direct mapping] Myosin light chain 5 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0005859 [muscle myosin complex] GO:0006936 [muscle contraction] GO:0006937 [regulation of muscle contraction] GO:0008307 [structural constituent of muscle] Show all	173 aa 19.5 kDa	No	0
MYL5-002 ENSP00000427153 ENST00000506838	Q02045 [Direct mapping] Myosin light chain 5 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0005859 [muscle myosin complex] GO:0006936 [muscle contraction] GO:0006937 [regulation of muscle contraction] GO:0008307 [structural constituent of muscle] Show all	132 aa 14.9 kDa	No	0
MYL5-004 ENSP00000425162 ENST00000511290	Q02045 [Direct mapping] Myosin light chain 5 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0005859 [muscle myosin complex] GO:0006936 [muscle contraction] GO:0006937 [regulation of muscle contraction] GO:0008307 [structural constituent of muscle] Show all	132 aa 14.9 kDa	No	0
MYL5-008 ENSP00000427317 ENST00000507804	D6RJ91 [Direct mapping] Myosin light chain 5 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	126 aa 14.1 kDa	No	0
MYL5-009 ENSP00000423118 ENST00000505477	Q02045 [Direct mapping] Myosin light chain 5 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0005859 [muscle myosin complex] GO:0006936 [muscle contraction] GO:0006937 [regulation of muscle contraction] GO:0008307 [structural constituent of muscle] Show all	132 aa 14.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.