Cell atlas - IFI30 - The Human Protein Atlas

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IFI30

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Vesicles

Human cell
	Cytosol
	Vesicles

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GENERAL INFORMATION
Gene name	IFI30
Gene description	Interferon, gamma-inducible protein 30
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & vesicles.
RNA cell category	Cell line enhanced (U-266/84, RPMI-8226, Daudi)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA026650
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/84, RPMI-8226, Daudi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & vesicles.

Main location

Vesicles (supported), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA026650	A-431	Vesicles
	HPA026650	A-431	Cell Junctions
	HPA026650	U-2 OS	Cytosol
	HPA026650	U-251 MG	Cytosol

GENE INFORMATION
Gene name	IFI30 (HGNC Symbol)
Synonyms	GILT, IFI-30, IP-30, IP30, MGC32056
Description	Interferon, gamma-inducible protein 30 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	18173162 - 18178117
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000216490 (version 83.38)
Entrez gene	10437
UniProt	P13284 (UniProt - Evidence at protein level)
neXtProt	NX_P13284
Antibodypedia	IFI30 antibodies

PROTEIN BROWSER

IFI30-001	IFI30-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IFI30-001 ENSP00000384886 ENST00000407280	P13284 [Direct mapping] Gamma-interferon-inducible lysosomal thiol reductase A0A024R7N7 [Target identity:100%; Query identity:100%] Interferon, gamma-inducible protein 30, isoform CRA_b Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005886 [plasma membrane] GO:0016667 [oxidoreductase activity, acting on a sulfur group of donors] GO:0019221 [cytokine-mediated signaling pathway] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030054 [cell junction] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0043202 [lysosomal lumen] GO:0043231 [intracellular membrane-bounded organelle] GO:0048147 [negative regulation of fibroblast proliferation] GO:0050821 [protein stabilization] GO:0055114 [oxidation-reduction process] GO:0060333 [interferon-gamma-mediated signaling pathway] Show all	250 aa 28 kDa	Yes	0
IFI30-003 ENSP00000470527 ENST00000597802	M0QZG3 [Direct mapping] Gamma-interferon-inducible lysosomal thiol reductase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		105 aa 11.5 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.