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IFI30

GENERAL INFORMATION

Gene name

 IFI30

Gene description

 Interferon, gamma-inducible protein 30

Protein class

 Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (Daudi, RPMI-8226, U-266/84)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, most abundant in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA026650
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026650

GENE INFORMATION

Gene name

 IFI30 (HGNC Symbol)

Synonyms

 GILT, IFI-30, IP-30, IP30, MGC32056

Description

 Interferon, gamma-inducible protein 30 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 18173162 - 18178117

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000216490 (version 83.38)

Entrez gene

 10437

UniProt

 P13284 (UniProt - Evidence at protein level)

neXtProt

 NX_P13284

Antibodypedia

 IFI30 antibodies

PROTEIN BROWSER
IFI30-001
IFI30-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IFI30-001
ENSP00000384886
ENST00000407280
P13284 [Direct mapping]
Gamma-interferon-inducible lysosomal thiol reductase
A0A024R7N7 [Target identity:100%; Query identity:100%]
Interferon, gamma-inducible protein 30, isoform CRA_b
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0016667 [oxidoreductase activity, acting on a sulfur group of donors]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030054 [cell junction]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050821 [protein stabilization]
GO:0055114 [oxidation-reduction process]
GO:0060333 [interferon-gamma-mediated signaling pathway]
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 250 aa
28 kDa 		Yes 0
IFI30-003
ENSP00000470527
ENST00000597802
M0QZG3 [Direct mapping]
Gamma-interferon-inducible lysosomal thiol reductase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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 105 aa
11.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.