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VAMP2

GENERAL INFORMATION

Gene name

 VAMP2

Gene description

 Vesicle-associated membrane protein 2 (synaptobrevin 2)

Protein class

 FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Not detected
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 VAMP2 (HGNC Symbol)

Synonyms

 SYB2, VAMP-2

Description

 Vesicle-associated membrane protein 2 (synaptobrevin 2) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 8159149 - 8163546

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000220205 (version 83.38)

Entrez gene

 6844

UniProt

 P63027 (UniProt - Evidence at protein level)

neXtProt

 NX_P63027

Antibodypedia

 VAMP2 antibodies

PROTEIN BROWSER
VAMP2-001
VAMP2-002
VAMP2-003
VAMP2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VAMP2-001
ENSP00000314214
ENST00000316509
P63027 [Direct mapping]
Vesicle-associated membrane protein 2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0000322 [storage vacuole]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005543 [phospholipid binding]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006461 [protein complex assembly]
GO:0006887 [exocytosis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006906 [vesicle fusion]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008021 [synaptic vesicle]
GO:0008022 [protein C-terminus binding]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009749 [response to glucose]
GO:0014047 [glutamate secretion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016192 [vesicle-mediated transport]
GO:0017022 [myosin binding]
GO:0017075 [syntaxin-1 binding]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0017157 [regulation of exocytosis]
GO:0019905 [syntaxin binding]
GO:0030054 [cell junction]
GO:0030136 [clathrin-coated vesicle]
GO:0030141 [secretory granule]
GO:0030667 [secretory granule membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0031201 [SNARE complex]
GO:0031410 [cytoplasmic vesicle]
GO:0031982 [vesicle]
GO:0032403 [protein complex binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0042589 [zymogen granule membrane]
GO:0042802 [identical protein binding]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0043005 [neuron projection]
GO:0043195 [terminal bouton]
GO:0043229 [intracellular organelle]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043308 [eosinophil degranulation]
GO:0043621 [protein self-association]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044306 [neuron projection terminus]
GO:0044325 [ion channel binding]
GO:0045202 [synapse]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050796 [regulation of insulin secretion]
GO:0060203 [clathrin-sculpted glutamate transport vesicle membrane]
GO:0060291 [long-term synaptic potentiation]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0061024 [membrane organization]
GO:0061025 [membrane fusion]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
GO:0070032 [synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex]
GO:0070033 [synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex]
GO:0070044 [synaptobrevin 2-SNAP-25-syntaxin-1a complex]
GO:0070062 [extracellular exosome]
GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane]
GO:0090316 [positive regulation of intracellular protein transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
Show all
 116 aa
12.7 kDa 		No 1
VAMP2-002
ENSP00000466995
ENST00000404970
K7ENK9 [Direct mapping]
Vesicle-associated membrane protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0006906 [vesicle fusion]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
Show all
 68 aa
7.8 kDa 		No 1
VAMP2-003
ENSP00000418572
ENST00000488857
F8WCA0 [Direct mapping]
Vesicle-associated membrane protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0006906 [vesicle fusion]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
Show all
 118 aa
12.9 kDa 		No 1
VAMP2-004
ENSP00000467399
ENST00000481878
J3QRU4 [Direct mapping]
Vesicle-associated membrane protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0006906 [vesicle fusion]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
Show all
 113 aa
12.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.