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EBF2

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GENERAL INFORMATION

Gene name

 EBF2

Gene description

 Early B-cell factor 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (ASC TERT1, U-2197, U-87 MG, U-138 MG)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (ASC TERT1, U-2197, U-87 MG, U-138 MG)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 EBF2 (HGNC Symbol)

Synonyms

 COE2, FLJ11500

Description

 Early B-cell factor 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. [provided by RefSeq, Oct 2011]

Chromosome

 8

Cytoband

 p21.2

Chromosome location (bp)

 25841730 - 26045397

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000221818 (version 83.38)

Entrez gene

 64641

UniProt

 Q9HAK2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9HAK2

Antibodypedia

 EBF2 antibodies

PROTEIN BROWSER
EBF2-001
EBF2-002
EBF2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EBF2-001
ENSP00000430241
ENST00000520164
Q9HAK2 [Direct mapping]
Transcription factor COE2
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001709 [cell fate determination]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0035563 [positive regulation of chromatin binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046983 [protein dimerization activity]
GO:0050873 [brown fat cell differentiation]
GO:0060612 [adipose tissue development]
Show all
 575 aa
62.6 kDa 		No 0
EBF2-002
ENSP00000386178
ENST00000408929
B7Z934 [Direct mapping]
Transcription factor COE2; cDNA FLJ55302, highly similar to Transcription factor COE2
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0046872 [metal ion binding]
GO:0046983 [protein dimerization activity]
Show all
 427 aa
46 kDa 		No 0
EBF2-201
ENSP00000437909
ENST00000535548
Q9HAK2 [Direct mapping]
Transcription factor COE2
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005634 [nucleus]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046983 [protein dimerization activity]
Show all
 264 aa
28.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.