Tissue expression of EBF2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	EBF2
Gene description	Early B-cell factor 2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adipose tissue)
GTEx:	Tissue enhanced (adipose tissue)
FANTOM5:	Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue)

GENE INFORMATION
Gene name	EBF2 (HGNC Symbol)
Synonyms	COE2, FLJ11500
Description	Early B-cell factor 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. [provided by RefSeq, Oct 2011]
Chromosome	8
Cytoband	p21.2
Chromosome location (bp)	25841730 - 26045397
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000221818 (version 83.38)
Entrez gene	64641
UniProt	Q9HAK2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9HAK2
Antibodypedia	EBF2 antibodies

PROTEIN BROWSER

EBF2-001	EBF2-002	EBF2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EBF2-001 ENSP00000430241 ENST00000520164	Q9HAK2 [Direct mapping] Transcription factor COE2 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001709 [cell fate determination] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0035563 [positive regulation of chromatin binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046983 [protein dimerization activity] GO:0050873 [brown fat cell differentiation] GO:0060612 [adipose tissue development] Show all	575 aa 62.6 kDa	No	0
EBF2-002 ENSP00000386178 ENST00000408929	B7Z934 [Direct mapping] Transcription factor COE2; cDNA FLJ55302, highly similar to Transcription factor COE2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0046872 [metal ion binding] GO:0046983 [protein dimerization activity] Show all	427 aa 46 kDa	No	0
EBF2-201 ENSP00000437909 ENST00000535548	Q9HAK2 [Direct mapping] Transcription factor COE2 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Show all	GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005634 [nucleus] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046983 [protein dimerization activity] Show all	264 aa 28.7 kDa	No	0