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AP4M1

GENERAL INFORMATION

Gene name

 AP4M1

Gene description

 Adaptor-related protein complex 4, mu 1 subunit

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, including testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA066774
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA066774

GENE INFORMATION

Gene name

 AP4M1 (HGNC Symbol)

Synonyms

 MU-4, MU-ARP2, SPG50

Description

 Adaptor-related protein complex 4, mu 1 subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100101549 - 100110345

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000221838 (version 83.38)

Entrez gene

 9179

UniProt

 O00189 (UniProt - Evidence at protein level)

neXtProt

 NX_O00189

Antibodypedia

 AP4M1 antibodies

PROTEIN BROWSER
AP4M1-001
AP4M1-002
AP4M1-006
AP4M1-008
AP4M1-010
AP4M1-014
AP4M1-015
AP4M1-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP4M1-001
ENSP00000352603
ENST00000359593
O00189 [Direct mapping]
AP-4 complex subunit mu-1
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000138 [Golgi trans cisterna]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005802 [trans-Golgi network]
GO:0005905 [coated pit]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006895 [Golgi to endosome transport]
GO:0016192 [vesicle-mediated transport]
GO:0030119 [AP-type membrane coat adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
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 453 aa
50 kDa 		No 0
AP4M1-002
ENSP00000401613
ENST00000438383
C9JWL4 [Direct mapping]
AP-4 complex subunit mu-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
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 311 aa
34.5 kDa 		No 0
AP4M1-006
ENSP00000403663
ENST00000429084
C9JC87 [Direct mapping]
AP-4 complex subunit mu-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
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 460 aa
50.7 kDa 		No 0
AP4M1-008
ENSP00000406676
ENST00000422582
C9IZL5 [Direct mapping]
AP-4 complex subunit mu-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
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 325 aa
35.7 kDa 		No 0
AP4M1-010
ENSP00000414286
ENST00000439416
C9JMG3 [Direct mapping]
AP-4 complex subunit mu-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
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 266 aa
29.7 kDa 		No 0
AP4M1-014
ENSP00000393723
ENST00000445295
H7C0A0 [Direct mapping]
AP-4 complex subunit mu-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 138 aa
15.6 kDa 		No 0
AP4M1-015
ENSP00000412185
ENST00000421755
O00189 [Direct mapping]
AP-4 complex subunit mu-1
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000138 [Golgi trans cisterna]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005802 [trans-Golgi network]
GO:0005905 [coated pit]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006895 [Golgi to endosome transport]
GO:0016192 [vesicle-mediated transport]
GO:0030119 [AP-type membrane coat adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 453 aa
50 kDa 		No 0
AP4M1-016
ENSP00000391585
ENST00000450807
H7BZV3 [Direct mapping]
AP-4 complex subunit mu-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
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 160 aa
17.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.