Expression of PSG7 in cancer - Summary - The Human Protein Atlas

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PSG7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PSG7
Gene description	Pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (BJ, HBF TERT88, U-2197)
HPA (normal tissue):	Tissue enhanced (placenta, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA046327
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046327

GENE INFORMATION
Gene name	PSG7
Synonyms
Description	Pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) (HGNC Symbol)
Entrez gene summary	This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Chromosome	19
Cytoband	q13.31
Chromosome location (bp)	42906822 - 43082671
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000221878 (version 83.38)
Entrez gene	5676
UniProt
neXtProt
Antibodypedia	PSG7 antibodies

PROTEIN BROWSER

PSG7-001	PSG7-003	PSG7-006	PSG7-201	PSG7-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PSG7-001 ENSP00000421986 ENST00000406070	A0A087WSZ1 [Direct mapping] Putative pregnancy-specific beta-1-glycoprotein 7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	419 aa 47 kDa	Yes	0
PSG7-003 ENSP00000470856 ENST00000446844	A0A087WT09 [Direct mapping] Putative pregnancy-specific beta-1-glycoprotein 7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	426 aa 47.7 kDa	Yes	0
PSG7-006 ENSP00000485117 ENST00000623675	A0A096LNM5 [Direct mapping] Putative pregnancy-specific beta-1-glycoprotein 7 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	297 aa 33.4 kDa	No	0
PSG7-201 ENSP00000480429 ENST00000617049	A0A087WWQ7 [Direct mapping] Putative pregnancy-specific beta-1-glycoprotein 7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	426 aa 47.7 kDa	Yes	0
PSG7-202 ENSP00000478484 ENST00000618424	A0A087WU99 [Direct mapping] Putative pregnancy-specific beta-1-glycoprotein 7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	419 aa 47.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.