Fields »
ABOUT
HELP
BLOG
PPP2R2A

GENERAL INFORMATION

Gene name

 PPP2R2A

Gene description

 Protein phosphatase 2, regulatory subunit B, alpha

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 3 antibodies.
HPA042122 , HPA042770 , HPA059497
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042122
HPA042770
HPA059497

GENE INFORMATION

Gene name

 PPP2R2A (HGNC Symbol)

Synonyms

 B55A, PR52A, PR55A

Description

 Protein phosphatase 2, regulatory subunit B, alpha (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

Chromosome

 8

Cytoband

 p21.2

Chromosome location (bp)

 26291491 - 26372680

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000221914 (version 83.38)

Entrez gene

 5520

UniProt

 P63151 (UniProt - Evidence at protein level)

neXtProt

 NX_P63151

Antibodypedia

 PPP2R2A antibodies

PROTEIN BROWSER
PPP2R2A-001
PPP2R2A-002
PPP2R2A-004
PPP2R2A-006
PPP2R2A-012
PPP2R2A-016
PPP2R2A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP2R2A-001
ENSP00000370113
ENST00000380737
P63151 [Direct mapping]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000159 [protein phosphatase type 2A complex]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000278 [mitotic cell cycle]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0007084 [mitotic nuclear envelope reassembly]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0010467 [gene expression]
GO:0034047 [regulation of protein phosphatase type 2A activity]
Show all
 447 aa
51.7 kDa 		No 0
PPP2R2A-002
ENSP00000325074
ENST00000315985
P63151 [Direct mapping]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000159 [protein phosphatase type 2A complex]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000278 [mitotic cell cycle]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0007084 [mitotic nuclear envelope reassembly]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0010467 [gene expression]
GO:0032403 [protein complex binding]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043278 [response to morphine]
GO:0048156 [tau protein binding]
GO:0051721 [protein phosphatase 2A binding]
Show all
 457 aa
53 kDa 		No 0
PPP2R2A-004
ENSP00000430320
ENST00000524169
E5RFR9 [Direct mapping]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0005515 [protein binding]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
Show all
 197 aa
23 kDa 		No 0
PPP2R2A-006
ENSP00000428705
ENST00000522535
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 3 aa
0.4 kDa 		No 0
PPP2R2A-012
ENSP00000428800
ENST00000523925
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 5 aa
0.6 kDa 		No 0
PPP2R2A-016
ENSP00000428165
ENST00000521557
E5RJV1 [Direct mapping]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 14 aa
1.6 kDa 		No 0
PPP2R2A-201
ENSP00000486025
ENST00000630149
A0A0D9SEU4 [Direct mapping]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0032259 [methylation]
GO:0034047 [regulation of protein phosphatase type 2A activity]
Show all
 33 aa
3.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.