Expression of APOL6 in cancer - Summary - The Human Protein Atlas

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APOL6

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	APOL6
Gene description	Apolipoprotein L, 6
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in several cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA029165 , HPA029167 , CAB028574
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029165	HPA029167	CAB028574

GENE INFORMATION
Gene name	APOL6 (HGNC Symbol)
Synonyms	APOL-VI, APOLVI
Description	Apolipoprotein L, 6 (HGNC Symbol)
Entrez gene summary	This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.3
Chromosome location (bp)	35648395 - 35668409
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000221963 (version 83.38)
Entrez gene	80830
UniProt	Q9BWW8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BWW8
Antibodypedia	APOL6 antibodies

PROTEIN BROWSER

APOL6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOL6-001 ENSP00000386280 ENST00000409652	Q9BWW8 [Direct mapping] Apolipoprotein L6 B3KTP4 [Target identity:100%; Query identity:100%] Apolipoprotein L, 6; Apolipoprotein L6; cDNA FLJ38562 fis, clone HCHON2004002, highly similar to Apolipoprotein-L6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0042157 [lipoprotein metabolic process] Show all	343 aa 38.1 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.