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APOL6

GENERAL INFORMATION

Gene name

 APOL6

Gene description

 Apolipoprotein L, 6

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at variable levels in several cell types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA029165 , HPA029167 , CAB028574
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 APOL6 (HGNC Symbol)

Synonyms

 APOL-VI, APOLVI

Description

 Apolipoprotein L, 6 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q12.3

Chromosome location (bp)

 35648395 - 35668409

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000221963 (version 83.38)

Entrez gene

 80830

UniProt

 Q9BWW8 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9BWW8

Antibodypedia

 APOL6 antibodies

PROTEIN BROWSER
APOL6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOL6-001
ENSP00000386280
ENST00000409652
Q9BWW8 [Direct mapping]
Apolipoprotein L6
B3KTP4 [Target identity:100%; Query identity:100%]
Apolipoprotein L, 6; Apolipoprotein L6; cDNA FLJ38562 fis, clone HCHON2004002, highly similar to Apolipoprotein-L6
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0042157 [lipoprotein metabolic process]
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 343 aa
38.1 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.