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Malignant cells displayed weak cytoplasmic staining or were negative. A few renal cancers and malignant carcinoids showed moderate immunoreactivity.
GENE INFORMATION
Gene name
LTA (HGNC Symbol)
Synonyms
LT, TNFB, TNFSF1
Description
Lymphotoxin alpha (HGNC Symbol)
Entrez gene summary
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]