Fields »
ABOUT
HELP
BLOG
LTA

GENERAL INFORMATION

Gene name

 LTA

Gene description

 Lymphotoxin alpha

Protein class

 Cancer-related genes
Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, spleen)
GTEx:Tissue enhanced (spleen, testis)
FANTOM5:Tissue enhanced (appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Extracellular staining in several tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 1 antibody.
HPA007729
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION

Gene name

 LTA (HGNC Symbol)

Synonyms

 LT, TNFB, TNFSF1

Description

 Lymphotoxin alpha (HGNC Symbol)

Entrez gene summary

 The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31572054 - 31574324

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000226979 (version 83.38)

Entrez gene

 4049

UniProt

 P01374 (UniProt - Evidence at protein level)

neXtProt

 NX_P01374

Antibodypedia

 LTA antibodies

PROTEIN BROWSER
LTA-001
LTA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LTA-001
ENSP00000413450
ENST00000418386
P01374 [Direct mapping]
Lymphotoxin-alpha
Q5STV3 [Target identity:100%; Query identity:100%]
LTA protein; Lymphotoxin alpha; Lymphotoxin alpha (TNF superfamily, member 1), isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0016020 [membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
Show all
 205 aa
22.3 kDa 		Yes 0
LTA-002
ENSP00000403495
ENST00000454783
P01374 [Direct mapping]
Lymphotoxin-alpha
Q5STV3 [Target identity:100%; Query identity:100%]
LTA protein; Lymphotoxin alpha; Lymphotoxin alpha (TNF superfamily, member 1), isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001666 [response to hypoxia]
GO:0002876 [positive regulation of chronic inflammatory response to antigenic stimulus]
GO:0002925 [positive regulation of humoral immune response mediated by circulating immunoglobulin]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0006959 [humoral immune response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007584 [response to nutrient]
GO:0016020 [membrane]
GO:0032496 [response to lipopolysaccharide]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042493 [response to drug]
GO:0043065 [positive regulation of apoptotic process]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048535 [lymph node development]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0060252 [positive regulation of glial cell proliferation]
Show all
 205 aa
22.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.