Cell atlas - LTB - The Human Protein Atlas

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LTB

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome

Human cell
	Centrosome

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GENERAL INFORMATION
Gene name	LTB
Gene description	Lymphotoxin beta (TNF superfamily, member 3)
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the centrosome.
RNA cell category	Cell line enhanced (Daudi, REH, HDLM-2, U-698, NB-4)
Protein evidence	Evidence at protein level
Main location	Localized to the Centrosome (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA048884
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Daudi, REH, HDLM-2, U-698, NB-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the centrosome.

Main location

Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048884	A-431	Centrosome
	HPA048884	RT4	Centrosome
	HPA048884	U-2 OS	Centrosome

GENE INFORMATION
Gene name	LTB (HGNC Symbol)
Synonyms	p33, TNFC, TNFSF3
Description	Lymphotoxin beta (TNF superfamily, member 3) (HGNC Symbol)
Entrez gene summary	Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31580525 - 31582522
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000227507 (version 83.38)
Entrez gene	4050
UniProt	Q06643 (UniProt - Evidence at protein level)
neXtProt	NX_Q06643
Antibodypedia	LTB antibodies

PROTEIN BROWSER

LTB-001	LTB-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LTB-001 ENSP00000410481 ENST00000429299	Q06643 [Direct mapping] Lymphotoxin-beta Q5STB2 [Target identity:100%; Query identity:100%] LTB protein; Lymphotoxin beta; Lymphotoxin beta (TNF superfamily, member 3); Lymphotoxin beta (TNF superfamily, member 3), isoform CRA_b Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0043588 [skin development] GO:0045084 [positive regulation of interleukin-12 biosynthetic process] GO:0048535 [lymph node development] Show all	244 aa 25.4 kDa	No	0
LTB-002 ENSP00000416113 ENST00000446745	Q06643 [Direct mapping] Lymphotoxin-beta Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005575 [cellular_component] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0016021 [integral component of membrane] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0045084 [positive regulation of interleukin-12 biosynthetic process] Show all	77 aa 7.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.