Expression of LTB in cancer - Summary - The Human Protein Atlas

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LTB

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LTB
Gene description	Lymphotoxin beta (TNF superfamily, member 3)
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Daudi, HDLM-2, NB-4, REH, U-698)
HPA (normal tissue):	Group enriched (appendix, lymph node, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA048884
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable) and head and neck cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048884

GENE INFORMATION
Gene name	LTB (HGNC Symbol)
Synonyms	p33, TNFC, TNFSF3
Description	Lymphotoxin beta (TNF superfamily, member 3) (HGNC Symbol)
Entrez gene summary	Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31580525 - 31582522
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000227507 (version 83.38)
Entrez gene	4050
UniProt	Q06643 (UniProt - Evidence at protein level)
neXtProt	NX_Q06643
Antibodypedia	LTB antibodies

PROTEIN BROWSER

LTB-001	LTB-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LTB-001 ENSP00000410481 ENST00000429299	Q06643 [Direct mapping] Lymphotoxin-beta Q5STB2 [Target identity:100%; Query identity:100%] LTB protein; Lymphotoxin beta; Lymphotoxin beta (TNF superfamily, member 3); Lymphotoxin beta (TNF superfamily, member 3), isoform CRA_b Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0043588 [skin development] GO:0045084 [positive regulation of interleukin-12 biosynthetic process] GO:0048535 [lymph node development] Show all	244 aa 25.4 kDa	No	0
LTB-002 ENSP00000416113 ENST00000446745	Q06643 [Direct mapping] Lymphotoxin-beta Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005575 [cellular_component] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0016021 [integral component of membrane] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0045084 [positive regulation of interleukin-12 biosynthetic process] Show all	77 aa 7.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.