Cell atlas - ORM1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ORM1
Gene description	Orosomucoid 1
Protein class	Cancer-related genes Candidate cardiovascular disease genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the Golgi apparatus. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enriched (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047725
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the Golgi apparatus. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Vesicles (approved)

Additional location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA047725	A-431	Vesicles
HPA047725	Hep G2	Golgi apparatus
HPA047725	U-2 OS	Vesicles

GENE INFORMATION
Gene name	ORM1
Synonyms
Description	Orosomucoid 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q32
Chromosome location (bp)	114323056 - 114326475
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000229314 (version 83.38)
Entrez gene	5004
UniProt	P02763 (UniProt - Evidence at protein level)
neXtProt	NX_P02763
Antibodypedia	ORM1 antibodies

PROTEIN BROWSER

ORM1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ORM1-001 ENSP00000259396 ENST00000259396	P02763 [Direct mapping] Alpha-1-acid glycoprotein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002682 [regulation of immune system process] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006810 [transport] GO:0006953 [acute-phase response] GO:0006954 [inflammatory response] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	201 aa 23.5 kDa	Yes	0