Expression of ORM1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ORM1
Gene description	Orosomucoid 1
Protein class	Cancer-related genes Candidate cardiovascular disease genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types, including liver and lymphoid cells with positivity in plasma.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 3 antibodies. HPA046438 , HPA057726 , CAB006265
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA046438	HPA057726	CAB006265

GENE INFORMATION
Gene name	ORM1
Synonyms
Description	Orosomucoid 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q32
Chromosome location (bp)	114323056 - 114326475
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000229314 (version 83.38)
Entrez gene	5004
UniProt	P02763 (UniProt - Evidence at protein level)
neXtProt	NX_P02763
Antibodypedia	ORM1 antibodies

PROTEIN BROWSER

ORM1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ORM1-001 ENSP00000259396 ENST00000259396	P02763 [Direct mapping] Alpha-1-acid glycoprotein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002682 [regulation of immune system process] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006810 [transport] GO:0006953 [acute-phase response] GO:0006954 [inflammatory response] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	201 aa 23.5 kDa	Yes	0