Expression of PGA3 in cancer - Summary - The Human Protein Atlas

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PGA3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PGA3
Gene description	Pepsinogen 3, group I (pepsinogen A)
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (stomach cancer)
HPA (cell line):	Cell line enhanced (BJ hTERT+, HMC-1, THP-1)
HPA (normal tissue):	Tissue enriched (stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in stomach.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA046875 , CAB026358
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046875	CAB026358

GENE INFORMATION
Gene name	PGA3
Synonyms
Description	Pepsinogen 3, group I (pepsinogen A) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	61203307 - 61213098
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000229859 (version 83.38)
Entrez gene	643834
UniProt	P0DJD8 (UniProt - Evidence at protein level)
neXtProt	NX_P0DJD8
Antibodypedia	PGA3 antibodies

PROTEIN BROWSER

PGA3-001	PGA3-007	PGA3-008	PGA3-009	PGA3-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGA3-001 ENSP00000322192 ENST00000325558	P0DJD8 [Direct mapping] Pepsin A-3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0007586 [digestion] GO:0030163 [protein catabolic process] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0097486 [multivesicular body lumen] Show all	388 aa 42 kDa	Yes	0
PGA3-007 ENSP00000439846 ENST00000538258	F5H0H6 [Direct mapping] Pepsin A-3; Pepsin A-4 Show all	Predicted intracellular proteins Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0030163 [protein catabolic process] Show all	128 aa 13.3 kDa	No	0
PGA3-008 ENSP00000440177 ENST00000543125	F5GXL4 [Direct mapping] Pepsin A-3; Pepsin A-4 Show all	Predicted intracellular proteins Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0030163 [protein catabolic process] Show all	234 aa 24.6 kDa	No	0
PGA3-009 ENSP00000442525 ENST00000543349	F5H7H3 [Direct mapping] Pepsin A-3 Show all	Predicted intracellular proteins Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0030163 [protein catabolic process] Show all	184 aa 19.7 kDa	No	0
PGA3-010 ENSP00000443732 ENST00000543505	F5H842 [Direct mapping] Pepsin A-3 Show all	Predicted intracellular proteins Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0030163 [protein catabolic process] Show all	265 aa 27.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.