Expression of TAPBP in cancer - Summary - The Human Protein Atlas

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TAPBP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TAPBP
Gene description	TAP binding protein (tapasin)
Protein class	Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA007066
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable) and melanoma (favourable).
Breast cancer p<0.001 Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007066

GENE INFORMATION
Gene name	TAPBP (HGNC Symbol)
Synonyms	TAPA
Description	TAP binding protein (tapasin) (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.32
Chromosome location (bp)	33299694 - 33314387
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000231925 (version 83.38)
Entrez gene	6892
UniProt	O15533 (UniProt - Evidence at protein level)
neXtProt	NX_O15533
Antibodypedia	TAPBP antibodies

PROTEIN BROWSER

TAPBP-001	TAPBP-006	TAPBP-007	TAPBP-008	TAPBP-010	TAPBP-206

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TAPBP-001 ENSP00000395701 ENST00000434618	O15533 [Direct mapping] Tapasin A0A024RCT1 [Target identity:100%; Query identity:100%] TAP binding protein (Tapasin), isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006461 [protein complex assembly] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0006955 [immune response] GO:0015433 [peptide antigen-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016021 [integral component of membrane] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0042288 [MHC class I protein binding] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042605 [peptide antigen binding] GO:0042824 [MHC class I peptide loading complex] GO:0042825 [TAP complex] GO:0042886 [amide transport] GO:0046978 [TAP1 binding] GO:0046979 [TAP2 binding] GO:0050823 [peptide antigen stabilization] GO:0051082 [unfolded protein binding] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] Show all	448 aa 47.6 kDa	Yes	1
TAPBP-006 ENSP00000419659 ENST00000489157	A0A0A0MT98 [Direct mapping] Tapasin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	361 aa 38.3 kDa	Yes	1
TAPBP-007 ENSP00000417949 ENST00000475304	A2AB90 [Direct mapping] Tapasin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] Show all	466 aa 49.5 kDa	Yes	1
TAPBP-008 ENSP00000404833 ENST00000426633	A0A0A0MSV9 [Direct mapping] Tapasin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002397 [MHC class I protein complex assembly] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0006952 [defense response] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0042824 [MHC class I peptide loading complex] Show all	504 aa 53.9 kDa	Yes	1
TAPBP-010 ENSP00000417523 ENST00000467025	C9JA35 [Direct mapping] Tapasin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] Show all	192 aa 20.3 kDa	Yes	0
TAPBP-206 ENSP00000387803 ENST00000456592	Q6P1N7 [Direct mapping] TAPBP protein; Tapasin Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		156 aa 16.4 kDa	Yes	0

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