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This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
O15533 [Direct mapping] Tapasin A0A024RCT1 [Target identity:100%; Query identity:100%] TAP binding protein (Tapasin), isoform CRA_c
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006461 [protein complex assembly] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0006955 [immune response] GO:0015433 [peptide antigen-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016021 [integral component of membrane] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0042288 [MHC class I protein binding] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042605 [peptide antigen binding] GO:0042824 [MHC class I peptide loading complex] GO:0042825 [TAP complex] GO:0042886 [amide transport] GO:0046978 [TAP1 binding] GO:0046979 [TAP2 binding] GO:0050823 [peptide antigen stabilization] GO:0051082 [unfolded protein binding] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002397 [MHC class I protein complex assembly] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0006952 [defense response] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0042824 [MHC class I peptide loading complex]
