Expression of HLA-B in cancer - Summary

GENERAL INFORMATION
Gene name	HLA-B
Gene description	Major histocompatibility complex, class I, B
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A-431, EFO-21, U-266/70)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in most cell types including epithelia and endothelial cells. Highest levels in monocyte-derived and lymphoid cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB015418
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in melanoma (favourable).
Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

CAB015418

GENE INFORMATION
Gene name	HLA-B (HGNC Symbol)
Synonyms	AS
Description	Major histocompatibility complex, class I, B (HGNC Symbol)
Entrez gene summary	HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31353872 - 31357188
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000234745 (version 83.38)
Entrez gene	3106
UniProt	P01889 (UniProt - Evidence at protein level), P30480 (UniProt - Evidence at protein level), P30486 (UniProt - Evidence at protein level), Q29836 (UniProt - Evidence at protein level), Q31610 (UniProt - Evidence at protein level), Q31612 (UniProt - Evidence at protein level)
neXtProt	NX_P01889, NX_P30480, NX_P30486, NX_Q29836, NX_Q31610, NX_Q31612
Antibodypedia	HLA-B antibodies

PROTEIN BROWSER

HLA-B-001	HLA-B-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HLA-B-001 ENSP00000399168 ENST00000412585	P01889 [Direct mapping] HLA class I histocompatibility antigen, B-7 alpha chain P30480 [Direct mapping] HLA class I histocompatibility antigen, B-42 alpha chain P30486 [Direct mapping] HLA class I histocompatibility antigen, B-48 alpha chain Q29836 [Direct mapping] HLA class I histocompatibility antigen, B-67 alpha chain Q31610 [Direct mapping] HLA class I histocompatibility antigen, B-81 alpha chain Q31612 [Direct mapping] HLA class I histocompatibility antigen, B-73 alpha chain E5FQ95 [Target identity:100%; Query identity:100%] MHC class I antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent] GO:0002667 [regulation of T cell anergy] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0009986 [cell surface] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0019882 [antigen processing and presentation] GO:0030670 [phagocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0032655 [regulation of interleukin-12 production] GO:0032675 [regulation of interleukin-6 production] GO:0042270 [protection from natural killer cell mediated cytotoxicity] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0050776 [regulation of immune response] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0070062 [extracellular exosome] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:2001198 [regulation of dendritic cell differentiation] Show all	362 aa 40.5 kDa	Yes	1
HLA-B-003 ENSP00000405931 ENST00000434333	F6U0H7 [Direct mapping] HLA class I histocompatibility antigen, B-46 alpha chain Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0006955 [immune response] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] Show all	246 aa 27.8 kDa	No	0