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Major histocompatibility complex, class I, B (HGNC Symbol)
Entrez gene summary
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
P01889 (UniProt - Evidence at protein level), P30480 (UniProt - Evidence at protein level), P30486 (UniProt - Evidence at protein level), Q29836 (UniProt - Evidence at protein level), Q31610 (UniProt - Evidence at protein level), Q31612 (UniProt - Evidence at protein level)
P01889 [Direct mapping] HLA class I histocompatibility antigen, B-7 alpha chain P30480 [Direct mapping] HLA class I histocompatibility antigen, B-42 alpha chain P30486 [Direct mapping] HLA class I histocompatibility antigen, B-48 alpha chain Q29836 [Direct mapping] HLA class I histocompatibility antigen, B-67 alpha chain Q31610 [Direct mapping] HLA class I histocompatibility antigen, B-81 alpha chain Q31612 [Direct mapping] HLA class I histocompatibility antigen, B-73 alpha chain E5FQ95 [Target identity:100%; Query identity:100%] MHC class I antigen
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent] GO:0002667 [regulation of T cell anergy] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0009986 [cell surface] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0019882 [antigen processing and presentation] GO:0030670 [phagocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0032655 [regulation of interleukin-12 production] GO:0032675 [regulation of interleukin-6 production] GO:0042270 [protection from natural killer cell mediated cytotoxicity] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0050776 [regulation of immune response] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0070062 [extracellular exosome] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:2001198 [regulation of dendritic cell differentiation]
F6U0H7 [Direct mapping] HLA class I histocompatibility antigen, B-46 alpha chain
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Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0006955 [immune response] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex]
