Expression of TXNDC5 in cancer - Summary

GENERAL INFORMATION
Gene name	TXNDC5
Gene description	Thioredoxin domain containing 5 (endoplasmic reticulum)
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

cytoplasmic expression in several tissue types, most abundant in a subset of leukocytes, exocrine pancreas and a subset of decidual cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA034677 , HPA034678
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA034677	HPA034678

GENE INFORMATION
Gene name	TXNDC5 (HGNC Symbol)
Synonyms	EndoPDI, ERp46, FLJ21353, FLJ90810, Hcc-2, MGC3178, PDIA15
Description	Thioredoxin domain containing 5 (endoplasmic reticulum) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010]
Chromosome	6
Cytoband	p24.3
Chromosome location (bp)	7881517 - 7910814
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000239264 (version 83.38)
Entrez gene	81567
UniProt	Q8NBS9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NBS9
Antibodypedia	TXNDC5 antibodies

PROTEIN BROWSER

TXNDC5-001	TXNDC5-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TXNDC5-001 ENSP00000369081 ENST00000379757	Q8NBS9 [Direct mapping] Thioredoxin domain-containing protein 5 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003756 [protein disulfide isomerase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006457 [protein folding] GO:0006892 [post-Golgi vesicle-mediated transport] GO:0008152 [metabolic process] GO:0016853 [isomerase activity] GO:0034976 [response to endoplasmic reticulum stress] GO:0043066 [negative regulation of apoptotic process] GO:0043202 [lysosomal lumen] GO:0043277 [apoptotic cell clearance] GO:0045454 [cell redox homeostasis] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	432 aa 47.6 kDa	Yes	0
TXNDC5-003 ENSP00000420784 ENST00000473453	Q8NBS9 [Direct mapping] Thioredoxin domain-containing protein 5 A0A024QZV0 [Target identity:100%; Query identity:100%] HCG1811539, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003756 [protein disulfide isomerase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006457 [protein folding] GO:0006892 [post-Golgi vesicle-mediated transport] GO:0008152 [metabolic process] GO:0016853 [isomerase activity] GO:0034976 [response to endoplasmic reticulum stress] GO:0043066 [negative regulation of apoptotic process] GO:0043202 [lysosomal lumen] GO:0043277 [apoptotic cell clearance] GO:0045454 [cell redox homeostasis] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	324 aa 36.2 kDa	No	0