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TXNDC5

GENERAL INFORMATION

Gene name

 TXNDC5

Gene description

 Thioredoxin domain containing 5 (endoplasmic reticulum)

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 cytoplasmic expression in several tissue types, most abundant in a subset of leukocytes, exocrine pancreas and a subset of decidual cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA034677 , HPA034678
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin050100150200250300350TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0510152025RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina050100150200250300Tags Per Million

GENE INFORMATION

Gene name

 TXNDC5 (HGNC Symbol)

Synonyms

 EndoPDI, ERp46, FLJ21353, FLJ90810, Hcc-2, MGC3178, PDIA15

Description

 Thioredoxin domain containing 5 (endoplasmic reticulum) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010]

Chromosome

 6

Cytoband

 p24.3

Chromosome location (bp)

 7881517 - 7910814

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000239264 (version 83.38)

Entrez gene

 81567

UniProt

 Q8NBS9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NBS9

Antibodypedia

 TXNDC5 antibodies

PROTEIN BROWSER
TXNDC5-001
TXNDC5-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TXNDC5-001
ENSP00000369081
ENST00000379757
Q8NBS9 [Direct mapping]
Thioredoxin domain-containing protein 5
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003756 [protein disulfide isomerase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006457 [protein folding]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008152 [metabolic process]
GO:0016853 [isomerase activity]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0043066 [negative regulation of apoptotic process]
GO:0043202 [lysosomal lumen]
GO:0043277 [apoptotic cell clearance]
GO:0045454 [cell redox homeostasis]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
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 432 aa
47.6 kDa 		Yes 0
TXNDC5-003
ENSP00000420784
ENST00000473453
Q8NBS9 [Direct mapping]
Thioredoxin domain-containing protein 5
A0A024QZV0 [Target identity:100%; Query identity:100%]
HCG1811539, isoform CRA_b
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003756 [protein disulfide isomerase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006457 [protein folding]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008152 [metabolic process]
GO:0016853 [isomerase activity]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0043066 [negative regulation of apoptotic process]
GO:0043202 [lysosomal lumen]
GO:0043277 [apoptotic cell clearance]
GO:0045454 [cell redox homeostasis]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 324 aa
36.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.