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TNFSF12

GENERAL INFORMATION

Gene name

 TNFSF12

Gene description

 Tumor necrosis factor (ligand) superfamily, member 12

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA052967
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TNFSF12 (HGNC Symbol)

Synonyms

 APO3L, DR3LG, TWEAK

Description

 Tumor necrosis factor (ligand) superfamily, member 12 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7548891 - 7557890

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000239697 (version 83.38)

Entrez gene

 8742

UniProt

 O43508 (UniProt - Evidence at protein level)

neXtProt

 NX_O43508

Antibodypedia

 TNFSF12 antibodies

PROTEIN BROWSER
TNFSF12-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNFSF12-001
ENSP00000293825
ENST00000293825
O43508 [Direct mapping]
Tumor necrosis factor ligand superfamily member 12 Tumor necrosis factor ligand superfamily member 12, membrane form Tumor necrosis factor ligand superfamily member 12, secreted form
Q4ACW9 [Target identity:100%; Query identity:100%]
HCG1991317, isoform CRA_b; TWEAK; Tumor necrosis factor (Ligand) superfamily, member 12
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0030154 [cell differentiation]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0043542 [endothelial cell migration]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0048471 [perinuclear region of cytoplasm]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
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 249 aa
27.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.