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APOBEC3G

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GENERAL INFORMATION

Gene name

 APOBEC3G

Gene description

 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Cell line enhanced (Karpas-707, HDLM-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (uncertain), Cytosol (uncertain)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA073637
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707, HDLM-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Nucleoplasm (uncertain), Cytosol (uncertain)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA073637 A-431 Nucleoplasm Spatial
Cytosol Spatial
HPA073637 RT4 Nucleoplasm Intensity
Cytosol Intensity
HPA073637 U-2 OS No staining    

GENE INFORMATION

Gene name

 APOBEC3G (HGNC Symbol)

Synonyms

 bK150C2.7, CEM15, dJ494G10.1, FLJ12740, MDS019

Description

 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G (HGNC Symbol)

Entrez gene summary

 This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 39040961 - 39087743

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000239713 (version 83.38)

Entrez gene

 60489

UniProt

 Q9HC16 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HC16

Antibodypedia

 APOBEC3G antibodies

PROTEIN BROWSER
APOBEC3G-001
APOBEC3G-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOBEC3G-001
ENSP00000385057
ENST00000407997
Q9HC16 [Direct mapping]
DNA dC->dU-editing enzyme APOBEC-3G
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003723 [RNA binding]
GO:0003824 [catalytic activity]
GO:0004126 [cytidine deaminase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0009972 [cytidine deamination]
GO:0010529 [negative regulation of transposition]
GO:0016032 [viral process]
GO:0016553 [base conversion or substitution editing]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
GO:0030529 [ribonucleoprotein complex]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0042803 [protein homodimerization activity]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0047844 [deoxycytidine deaminase activity]
GO:0048525 [negative regulation of viral process]
GO:0051607 [defense response to virus]
GO:0070383 [DNA cytosine deamination]
Show all
 384 aa
46.4 kDa 		No 0
APOBEC3G-201
ENSP00000413376
ENST00000452957
Q9HC16 [Direct mapping]
DNA dC->dU-editing enzyme APOBEC-3G
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003723 [RNA binding]
GO:0003824 [catalytic activity]
GO:0004126 [cytidine deaminase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0009972 [cytidine deamination]
GO:0010529 [negative regulation of transposition]
GO:0016032 [viral process]
GO:0016553 [base conversion or substitution editing]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
GO:0030529 [ribonucleoprotein complex]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0042803 [protein homodimerization activity]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0047844 [deoxycytidine deaminase activity]
GO:0048525 [negative regulation of viral process]
GO:0051607 [defense response to virus]
GO:0070383 [DNA cytosine deamination]
Show all
 384 aa
46.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.