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APOBEC3G

GENERAL INFORMATION

Gene name

 APOBEC3G

Gene description

 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HDLM-2, Karpas-707)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, including immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA001812
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable), cervical cancer (favourable), breast cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Cervical cancer p<0.001
Breast cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001812

GENE INFORMATION

Gene name

 APOBEC3G (HGNC Symbol)

Synonyms

 bK150C2.7, CEM15, dJ494G10.1, FLJ12740, MDS019

Description

 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G (HGNC Symbol)

Entrez gene summary

 This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 39040961 - 39087743

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000239713 (version 83.38)

Entrez gene

 60489

UniProt

 Q9HC16 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HC16

Antibodypedia

 APOBEC3G antibodies

PROTEIN BROWSER
APOBEC3G-001
APOBEC3G-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOBEC3G-001
ENSP00000385057
ENST00000407997
Q9HC16 [Direct mapping]
DNA dC->dU-editing enzyme APOBEC-3G
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000932 [cytoplasmic mRNA processing body]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003723 [RNA binding]
GO:0003824 [catalytic activity]
GO:0004126 [cytidine deaminase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0009972 [cytidine deamination]
GO:0010529 [negative regulation of transposition]
GO:0016032 [viral process]
GO:0016553 [base conversion or substitution editing]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
GO:0030529 [ribonucleoprotein complex]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0042803 [protein homodimerization activity]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0047844 [deoxycytidine deaminase activity]
GO:0048525 [negative regulation of viral process]
GO:0051607 [defense response to virus]
GO:0070383 [DNA cytosine deamination]
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 384 aa
46.4 kDa 		No 0
APOBEC3G-201
ENSP00000413376
ENST00000452957
Q9HC16 [Direct mapping]
DNA dC->dU-editing enzyme APOBEC-3G
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003723 [RNA binding]
GO:0003824 [catalytic activity]
GO:0004126 [cytidine deaminase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0009972 [cytidine deamination]
GO:0010529 [negative regulation of transposition]
GO:0016032 [viral process]
GO:0016553 [base conversion or substitution editing]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
GO:0030529 [ribonucleoprotein complex]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0042803 [protein homodimerization activity]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0047844 [deoxycytidine deaminase activity]
GO:0048525 [negative regulation of viral process]
GO:0051607 [defense response to virus]
GO:0070383 [DNA cytosine deamination]
Show all
 384 aa
46.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.