Expression of ARHGEF25 in cancer - Summary - The Human Protein Atlas

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ARHGEF25

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARHGEF25
Gene description	Rho guanine nucleotide exchange factor (GEF) 25
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (RH-30, SH-SY5Y)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 1 antibody. HPA052016
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052016

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most of the malignant tissues displayed weak to moderate cytoplasmic positivity. Several cases of malignant lymphomas, lung, skin, gastric, colorectal, prostate and cervical cancers were negative.

GENE INFORMATION
Gene name	ARHGEF25 (HGNC Symbol)
Synonyms	GEFT, p63RhoGEF
Description	Rho guanine nucleotide exchange factor (GEF) 25 (HGNC Symbol)
Entrez gene summary	Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	57610180 - 57619379
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000240771 (version 83.38)
Entrez gene	115557
UniProt	Q86VW2 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VW2
Antibodypedia	ARHGEF25 antibodies

PROTEIN BROWSER

ARHGEF25-001	ARHGEF25-003	ARHGEF25-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGEF25-001 ENSP00000286494 ENST00000286494	Q86VW2 [Direct mapping] Rho guanine nucleotide exchange factor 25 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0030016 [myofibril] GO:0030017 [sarcomere] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	580 aa 63.8 kDa	No	0
ARHGEF25-003 ENSP00000335560 ENST00000333972	Q86VW2 [Direct mapping] Rho guanine nucleotide exchange factor 25 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0030016 [myofibril] GO:0030017 [sarcomere] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	619 aa 68.1 kDa	No	0
ARHGEF25-201 ENSP00000484303 ENST00000616622	Q86VW2 [Direct mapping] Rho guanine nucleotide exchange factor 25 A0A024RBA8 [Target identity:100%; Query identity:100%] HCG2015932, isoform CRA_b Show all	Predicted intracellular proteins Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0030016 [myofibril] GO:0030017 [sarcomere] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	474 aa 53.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.