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ARHGEF25

GENERAL INFORMATION

Gene name

 ARHGEF25

Gene description

 Rho guanine nucleotide exchange factor (GEF) 25

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Uncertain based on 1 antibody.
HPA052016
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080100120TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin020406080100RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina050100150200250300350Tags Per Million

GENE INFORMATION

Gene name

 ARHGEF25 (HGNC Symbol)

Synonyms

 GEFT, p63RhoGEF

Description

 Rho guanine nucleotide exchange factor (GEF) 25 (HGNC Symbol)

Entrez gene summary

 Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 57610180 - 57619379

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000240771 (version 83.38)

Entrez gene

 115557

UniProt

 Q86VW2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86VW2

Antibodypedia

 ARHGEF25 antibodies

PROTEIN BROWSER
ARHGEF25-001
ARHGEF25-003
ARHGEF25-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF25-001
ENSP00000286494
ENST00000286494
Q86VW2 [Direct mapping]
Rho guanine nucleotide exchange factor 25
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 580 aa
63.8 kDa 		No 0
ARHGEF25-003
ENSP00000335560
ENST00000333972
Q86VW2 [Direct mapping]
Rho guanine nucleotide exchange factor 25
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 619 aa
68.1 kDa 		No 0
ARHGEF25-201
ENSP00000484303
ENST00000616622
Q86VW2 [Direct mapping]
Rho guanine nucleotide exchange factor 25
A0A024RBA8 [Target identity:100%; Query identity:100%]
HCG2015932, isoform CRA_b
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Predicted intracellular proteins
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 474 aa
53.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.