Tissue expression of AMACR - Summary - The Human Protein Atlas

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AMACR

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	AMACR
Gene description	Alpha-methylacyl-CoA racemase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression in several tissues, most abundant in renal tubules and liver.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA019527 , HPA020912 , CAB001809
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	AMACR (HGNC Symbol)
Synonyms	RACE
Description	Alpha-methylacyl-CoA racemase (HGNC Symbol)
Entrez gene summary	This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]
Chromosome	5
Cytoband	p13.2
Chromosome location (bp)	33986178 - 34008108
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000242110 (version 83.38)
Entrez gene	23600
UniProt	Q9UHK6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHK6
Antibodypedia	AMACR antibodies

PROTEIN BROWSER

AMACR-001	AMACR-002	AMACR-003	AMACR-004	AMACR-005	AMACR-006	AMACR-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMACR-001 ENSP00000334424 ENST00000335606	Q9UHK6 [Direct mapping] Alpha-methylacyl-CoA racemase Show all	Enzymes ENZYME proteins Isomerase Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005102 [receptor binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0006699 [bile acid biosynthetic process] GO:0008111 [alpha-methylacyl-CoA racemase activity] GO:0008206 [bile acid metabolic process] GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	382 aa 42.4 kDa	No	0
AMACR-002 ENSP00000371504 ENST00000382072	Q9UHK6 [Direct mapping] Alpha-methylacyl-CoA racemase Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005102 [receptor binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0006699 [bile acid biosynthetic process] GO:0008111 [alpha-methylacyl-CoA racemase activity] GO:0008206 [bile acid metabolic process] GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	198 aa 22.2 kDa	No	0
AMACR-003 ENSP00000424351 ENST00000502637	D6RB81 [Direct mapping] Alpha-methylacyl-CoA racemase Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	367 aa 40.7 kDa	No	0
AMACR-004 ENSP00000476965 ENST00000426255	V9GYP4 [Direct mapping] Alpha-methylacyl-CoA racemase Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	288 aa 31.7 kDa	No	0
AMACR-005 ENSP00000477411 ENST00000512079	V9GZ45 [Direct mapping] Alpha-methylacyl-CoA racemase Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	260 aa 28.5 kDa	No	0
AMACR-006 ENSP00000477108 ENST00000382068	V9GYU9 [Direct mapping] Alpha-methylacyl-CoA racemase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	281 aa 30.8 kDa	No	0
AMACR-008 ENSP00000371517 ENST00000382085	Q9UHK6 [Direct mapping] Alpha-methylacyl-CoA racemase Show all	Enzymes ENZYME proteins Isomerase Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005102 [receptor binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0006699 [bile acid biosynthetic process] GO:0008111 [alpha-methylacyl-CoA racemase activity] GO:0008206 [bile acid metabolic process] GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	394 aa 43.9 kDa	No	0

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The Human Protein Atlas

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