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ARHGDIG

GENERAL INFORMATION

Gene name

 ARHGDIG

Gene description

 Rho GDP dissociation inhibitor (GDI) gamma

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (HEK93, MCF7, SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (cerebral cortex, duodenum)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ARHGDIG (HGNC Symbol)

Synonyms

 RHOGDI-3

Description

 Rho GDP dissociation inhibitor (GDI) gamma (HGNC Symbol)

Entrez gene summary

 The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 268727 - 283010

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000242173 (version 83.38)

Entrez gene

 398

UniProt

 Q99819 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99819

Antibodypedia

 ARHGDIG antibodies

PROTEIN BROWSER
ARHGDIG-001
ARHGDIG-002
ARHGDIG-004
ARHGDIG-005
ARHGDIG-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGDIG-001
ENSP00000219409
ENST00000219409
Q99819 [Direct mapping]
Rho GDP-dissociation inhibitor 3
F1T0H7 [Target identity:100%; Query identity:100%]
HCG1985507, isoform CRA_a; Rho GDP-dissociation inhibitor 3
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   SignalP predicted secreted proteins
Predicted intracellular proteins
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GO:0005092 [GDP-dissociation inhibitor activity]
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030695 [GTPase regulator activity]
GO:0032880 [regulation of protein localization]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
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 225 aa
25.1 kDa 		No 0
ARHGDIG-002
ENSP00000410541
ENST00000414650
C9J3B5 [Direct mapping]
Rho GDP-dissociation inhibitor 3
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Predicted intracellular proteins
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GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005737 [cytoplasm]
GO:0050790 [regulation of catalytic activity]
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 116 aa
13.4 kDa 		No 0
ARHGDIG-004
ENSP00000404435
ENST00000447871
A2ID99 [Direct mapping]
Rho GDP dissociation inhibitor (GDI) gamma; Rho GDP-dissociation inhibitor 3
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   SignalP predicted secreted proteins
Predicted intracellular proteins
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GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005737 [cytoplasm]
GO:0050790 [regulation of catalytic activity]
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 178 aa
19.6 kDa 		No 0
ARHGDIG-005
ENSP00000408037
ENST00000412541
C9JR26 [Direct mapping]
Rho GDP-dissociation inhibitor 3
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Predicted intracellular proteins
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GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005737 [cytoplasm]
GO:0050790 [regulation of catalytic activity]
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 76 aa
8.3 kDa 		No 0
ARHGDIG-006
ENSP00000397395
ENST00000435035
C9J9L9 [Direct mapping]
Rho GDP-dissociation inhibitor 3
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Predicted intracellular proteins
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GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005737 [cytoplasm]
GO:0050790 [regulation of catalytic activity]
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 136 aa
14.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.