Expression of ARFGAP3 in cancer - Summary

GENERAL INFORMATION
Gene name	ARFGAP3
Gene description	ADP-ribosylation factor GTPase activating protein 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types, most abundant in glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA000638
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and thyroid cancer (unfavourable).
Endometrial cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA000638

GENE INFORMATION
Gene name	ARFGAP3 (HGNC Symbol)
Synonyms	ARFGAP1
Description	ADP-ribosylation factor GTPase activating protein 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]
Chromosome	22
Cytoband	q13.2
Chromosome location (bp)	42796502 - 42858106
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000242247 (version 83.38)
Entrez gene	26286
UniProt	Q9NP61 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NP61
Antibodypedia	ARFGAP3 antibodies

PROTEIN BROWSER

ARFGAP3-001	ARFGAP3-003	ARFGAP3-004	ARFGAP3-005	ARFGAP3-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARFGAP3-001 ENSP00000263245 ENST00000263245	Q9NP61 [Direct mapping] ADP-ribosylation factor GTPase-activating protein 3 A0A024R4U0 [Target identity:100%; Query identity:100%] ADP-ribosylation factor GTPase activating protein 3, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0006886 [intracellular protein transport] GO:0008565 [protein transporter activity] GO:0009306 [protein secretion] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	516 aa 56.9 kDa	No	0
ARFGAP3-003 ENSP00000403520 ENST00000454099	B0QYV8 [Direct mapping] ADP-ribosylation factor GTPase-activating protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0043547 [positive regulation of GTPase activity] Show all	152 aa 16.4 kDa	No	0
ARFGAP3-004 ENSP00000407734 ENST00000435208	B0QYV9 [Direct mapping] ADP-ribosylation factor GTPase-activating protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0043547 [positive regulation of GTPase activity] Show all	92 aa 10.2 kDa	No	0
ARFGAP3-005 ENSP00000403995 ENST00000453516	H0Y6A0 [Direct mapping] ADP-ribosylation factor GTPase-activating protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		273 aa 30 kDa	No	0
ARFGAP3-010 ENSP00000388791 ENST00000437119	Q9NP61 [Direct mapping] ADP-ribosylation factor GTPase-activating protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0006886 [intracellular protein transport] GO:0008565 [protein transporter activity] GO:0009306 [protein secretion] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	472 aa 52 kDa	No	0