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ARFGAP3

GENERAL INFORMATION

Gene name

 ARFGAP3

Gene description

 ADP-ribosylation factor GTPase activating protein 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types, most abundant in glandular cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA000638
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARFGAP3 (HGNC Symbol)

Synonyms

 ARFGAP1

Description

 ADP-ribosylation factor GTPase activating protein 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]

Chromosome

 22

Cytoband

 q13.2

Chromosome location (bp)

 42796502 - 42858106

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000242247 (version 83.38)

Entrez gene

 26286

UniProt

 Q9NP61 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NP61

Antibodypedia

 ARFGAP3 antibodies

PROTEIN BROWSER
ARFGAP3-001
ARFGAP3-003
ARFGAP3-004
ARFGAP3-005
ARFGAP3-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARFGAP3-001
ENSP00000263245
ENST00000263245
Q9NP61 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 3
A0A024R4U0 [Target identity:100%; Query identity:100%]
ADP-ribosylation factor GTPase activating protein 3, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0009306 [protein secretion]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
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 516 aa
56.9 kDa 		No 0
ARFGAP3-003
ENSP00000403520
ENST00000454099
B0QYV8 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0043547 [positive regulation of GTPase activity]
Show all
 152 aa
16.4 kDa 		No 0
ARFGAP3-004
ENSP00000407734
ENST00000435208
B0QYV9 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0043547 [positive regulation of GTPase activity]
Show all
 92 aa
10.2 kDa 		No 0
ARFGAP3-005
ENSP00000403995
ENST00000453516
H0Y6A0 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 273 aa
30 kDa 		No 0
ARFGAP3-010
ENSP00000388791
ENST00000437119
Q9NP61 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0009306 [protein secretion]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 472 aa
52 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.