Expression of EFNA4 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

EFNA4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EFNA4
Gene description	Ephrin-A4
Protein class	Predicted membrane proteins Predicted secreted proteins RAS pathway related proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB021350
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), stomach cancer (favourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Stomach cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB021350

GENE INFORMATION
Gene name	EFNA4 (HGNC Symbol)
Synonyms	EPLG4, LERK4
Description	Ephrin-A4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	155063731 - 155069553
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000243364 (version 83.38)
Entrez gene	1945
UniProt	P52798 (UniProt - Evidence at protein level)
neXtProt	NX_P52798
Antibodypedia	EFNA4 antibodies

PROTEIN BROWSER

EFNA4-001	EFNA4-002	EFNA4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EFNA4-001 ENSP00000357394 ENST00000368409	P52798 [Direct mapping] Ephrin-A4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Show all	GO:0005005 [transmembrane-ephrin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0030316 [osteoclast differentiation] GO:0031225 [anchored component of membrane] GO:0046849 [bone remodeling] GO:0046875 [ephrin receptor binding] GO:0048013 [ephrin receptor signaling pathway] Show all	201 aa 22.4 kDa	Yes	1
EFNA4-002 ENSP00000352789 ENST00000359751	P52798 [Direct mapping] Ephrin-A4 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Show all	GO:0005005 [transmembrane-ephrin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0030316 [osteoclast differentiation] GO:0031225 [anchored component of membrane] GO:0046849 [bone remodeling] GO:0046875 [ephrin receptor binding] GO:0048013 [ephrin receptor signaling pathway] Show all	193 aa 21.7 kDa	Yes	0
EFNA4-003 ENSP00000414378 ENST00000427683	P52798 [Direct mapping] Ephrin-A4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Show all	GO:0005005 [transmembrane-ephrin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0030316 [osteoclast differentiation] GO:0031225 [anchored component of membrane] GO:0046849 [bone remodeling] GO:0046875 [ephrin receptor binding] GO:0048013 [ephrin receptor signaling pathway] Show all	207 aa 22.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.