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EFNA4

GENERAL INFORMATION

Gene name

 EFNA4

Gene description

 Ephrin-A4

Protein class

 Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB021350
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 EFNA4 (HGNC Symbol)

Synonyms

 EPLG4, LERK4

Description

 Ephrin-A4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 155063731 - 155069553

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000243364 (version 83.38)

Entrez gene

 1945

UniProt

 P52798 (UniProt - Evidence at protein level)

neXtProt

 NX_P52798

Antibodypedia

 EFNA4 antibodies

PROTEIN BROWSER
EFNA4-001
EFNA4-002
EFNA4-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EFNA4-001
ENSP00000357394
ENST00000368409
P52798 [Direct mapping]
Ephrin-A4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Show all
GO:0005005 [transmembrane-ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007267 [cell-cell signaling]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0030316 [osteoclast differentiation]
GO:0031225 [anchored component of membrane]
GO:0046849 [bone remodeling]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 201 aa
22.4 kDa 		Yes 1
EFNA4-002
ENSP00000352789
ENST00000359751
P52798 [Direct mapping]
Ephrin-A4
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Show all
GO:0005005 [transmembrane-ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007267 [cell-cell signaling]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0030316 [osteoclast differentiation]
GO:0031225 [anchored component of membrane]
GO:0046849 [bone remodeling]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 193 aa
21.7 kDa 		Yes 0
EFNA4-003
ENSP00000414378
ENST00000427683
P52798 [Direct mapping]
Ephrin-A4
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Show all
GO:0005005 [transmembrane-ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007267 [cell-cell signaling]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0030316 [osteoclast differentiation]
GO:0031225 [anchored component of membrane]
GO:0046849 [bone remodeling]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 207 aa
22.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.