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LEFTY1

GENERAL INFORMATION

Gene name

 LEFTY1

Gene description

 Left-right determination factor 1

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (colorectal cancer)
HPA (cell line):Cell line enriched (NTERA-2)
HPA (normal tissue):Tissue enhanced (colon, rectum)

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Cytoplasmic expression in colon, rectum and pancreas.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA047883 , HPA056210
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA047883
HPA056210

GENE INFORMATION

Gene name

 LEFTY1 (HGNC Symbol)

Synonyms

 LEFTB, LEFTYB

Description

 Left-right determination factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q42.12

Chromosome location (bp)

 225886282 - 225911382

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000243709 (version 83.38)

Entrez gene

 10637

UniProt

 O75610 (UniProt - Evidence at transcript level)

neXtProt

 NX_O75610

Antibodypedia

 LEFTY1 antibodies

PROTEIN BROWSER
LEFTY1-001
LEFTY1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LEFTY1-001
ENSP00000272134
ENST00000272134
O75610 [Direct mapping]
Left-right determination factor 1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003007 [heart morphogenesis]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007368 [determination of left/right symmetry]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016049 [cell growth]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
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 366 aa
40.9 kDa 		Yes 0
LEFTY1-002
ENSP00000479837
ENST00000492457
A0A087WW09 [Direct mapping]
Left-right determination factor 1
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Predicted intracellular proteins
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GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016049 [cell growth]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
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 64 aa
7.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.