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LEFTY1

GENERAL INFORMATION

Gene name

 LEFTY1

Gene description

 Left-right determination factor 1

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (colon, rectum)
GTEx:Group enriched (colon, pancreas)
FANTOM5:Tissue enhanced (colon, epididymis, pancreas)

Protein evidence

 Evidence at transcript level

Protein expression

 Cytoplasmic expression in colon, rectum and pancreas.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA047883 , HPA056210
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, rectum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, pancreas)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, epididymis, pancreas)

GENE INFORMATION

Gene name

 LEFTY1 (HGNC Symbol)

Synonyms

 LEFTB, LEFTYB

Description

 Left-right determination factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q42.12

Chromosome location (bp)

 225886282 - 225911382

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000243709 (version 83.38)

Entrez gene

 10637

UniProt

 O75610 (UniProt - Evidence at transcript level)

neXtProt

 NX_O75610

Antibodypedia

 LEFTY1 antibodies

PROTEIN BROWSER
LEFTY1-001
LEFTY1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LEFTY1-001
ENSP00000272134
ENST00000272134
O75610 [Direct mapping]
Left-right determination factor 1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003007 [heart morphogenesis]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007368 [determination of left/right symmetry]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016049 [cell growth]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
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 366 aa
40.9 kDa 		Yes 0
LEFTY1-002
ENSP00000479837
ENST00000492457
A0A087WW09 [Direct mapping]
Left-right determination factor 1
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Predicted intracellular proteins
Show all
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016049 [cell growth]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
Show all
 64 aa
7.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.