Expression of ACY1 in cancer - Summary - The Human Protein Atlas

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ACY1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACY1
Gene description	Aminoacylase 1
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Group enriched (duodenum, kidney, liver, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in hepatocytes and renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 3 antibodies. HPA036174 , HPA036175 , CAB003695
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036174	HPA036175	CAB003695

GENE INFORMATION
Gene name	ACY1
Synonyms
Description	Aminoacylase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010]
Chromosome	3
Cytoband	p21.2
Chromosome location (bp)	51983340 - 51989197
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000243989 (version 83.38)
Entrez gene	95
UniProt	Q03154 (UniProt - Evidence at protein level)
neXtProt	NX_Q03154
Antibodypedia	ACY1 antibodies

PROTEIN BROWSER

ACY1-001	ACY1-006	ACY1-007	ACY1-008	ACY1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACY1-001 ENSP00000384296 ENST00000404366	Q03154 [Direct mapping] Aminoacylase-1 V9HWA0 [Target identity:100%; Query identity:100%] Aminoacylase-1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004046 [aminoacylase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006520 [cellular amino acid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0008237 [metallopeptidase activity] GO:0016787 [hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	408 aa 45.9 kDa	No	0
ACY1-006 ENSP00000419262 ENST00000476854	Q03154 [Direct mapping] Aminoacylase-1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004046 [aminoacylase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006520 [cellular amino acid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0008237 [metallopeptidase activity] GO:0016787 [hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	343 aa 38.6 kDa	No	0
ACY1-007 ENSP00000417056 ENST00000476351	Q03154 [Direct mapping] Aminoacylase-1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004046 [aminoacylase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006520 [cellular amino acid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0008237 [metallopeptidase activity] GO:0016787 [hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	373 aa 42.2 kDa	No	0
ACY1-008 ENSP00000417618 ENST00000494103	Q03154 [Direct mapping] Aminoacylase-1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004046 [aminoacylase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006520 [cellular amino acid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0008237 [metallopeptidase activity] GO:0016787 [hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	336 aa 37.6 kDa	No	0
ACY1-011 ENSP00000419830 ENST00000469863	C9JYZ0 [Direct mapping] Aminoacylase-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004046 [aminoacylase activity] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006520 [cellular amino acid metabolic process] GO:0008152 [metabolic process] GO:0008237 [metallopeptidase activity] GO:0016787 [hydrolase activity] Show all	228 aa 25.8 kDa	No	0

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The Human Protein Atlas

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