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PGAM5

GENERAL INFORMATION

Gene name

 PGAM5

Gene description

 PGAM family member 5, serine/threonine protein phosphatase, mitochondrial

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA036978 , HPA036979 , CAB068215
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036978
HPA036979
CAB068215

GENE INFORMATION

Gene name

 PGAM5 (HGNC Symbol)

Synonyms

 BXLBv68, MGC5352

Description

 PGAM family member 5, serine/threonine protein phosphatase, mitochondrial (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

 q24.33

Chromosome location (bp)

 132710819 - 132722734

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000247077 (version 83.38)

Entrez gene

 192111

UniProt

 Q96HS1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96HS1

Antibodypedia

 PGAM5 antibodies

PROTEIN BROWSER
PGAM5-001
PGAM5-004
PGAM5-005
PGAM5-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PGAM5-001
ENSP00000321503
ENST00000317555
Q96HS1 [Direct mapping]
Serine/threonine-protein phosphatase PGAM5, mitochondrial
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Enzymes
   ENZYME proteins
   Hydrolases
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006470 [protein dephosphorylation]
GO:0009400 [receptor signaling protein serine/threonine phosphatase activity]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0032403 [protein complex binding]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0070266 [necroptotic process]
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 255 aa
28 kDa 		Yes 0
PGAM5-004
ENSP00000440372
ENST00000543955
F5GXG4 [Direct mapping]
Serine/threonine-protein phosphatase PGAM5, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 140 aa
15.9 kDa 		No 0
PGAM5-005
ENSP00000438465
ENST00000498926
Q96HS1 [Direct mapping]
Serine/threonine-protein phosphatase PGAM5, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006470 [protein dephosphorylation]
GO:0009400 [receptor signaling protein serine/threonine phosphatase activity]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0032403 [protein complex binding]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0070266 [necroptotic process]
Show all
 289 aa
32 kDa 		Yes 0
PGAM5-006
ENSP00000409537
ENST00000454808
F5GXG4 [Direct mapping]
Serine/threonine-protein phosphatase PGAM5, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 140 aa
15.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.